| Qualifier | NOTE |
| Definition | any comment or additional information |
| Value Format | "free text" |
| Example | <INSDQualifier_value>Heme (covalent)</INSDQualifier_value> |
| Comment | The “NOTE” qualifier is mandatory for the feature keys: BINDING; CARBOHYD; CROSSLNK; DISULFID; DNA_BIND; DOMAIN; LIPID; METAL; MOD_RES; NP_BIND and ZN_FING |